Gene Signatures of Progression and Metastasis in Renal Cell Cancer

Purpose: To address progression, metastasis and the clinical heterogeneity of Renal Cell Cancer (RCC). Material and Methods: Transcriptional profiling with oligonucleotide microarrays (22,283 genes) was performed on 53 RCC tumors, 22 non-RCC renal tumors and 24 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified. Gene expression was correlated to disease progression and a metastasis gene signature was derived. Results: Gene signatures were identified for each tumor type with 100% accuracy. Differentially expressed genes…