Impact of aspirin and comedications on healing of biopsy-induced erosions

Aims: Aspirin and non-aspirin NSAIDS are known to induce lesions in the upper GI tract. Other drugs are thought either to aggravate (steroids, Cox-2 inhibitors, clopidogrel) or to speed up (proton-pump inhibitors) healing of erosions. Prospective data on this topic are scarce. Methods: Prospective, randomised, cross-over, placebo-controlled trial in 10 healthy volunteers (HV; H.pylori negative). HV and investigators were blinded for the comedications, which were given during the first 2 weeks: placebo, clopidogrel 75mg/d, rofecoxib 25mg/d, prednisolone 10mg/d, or esomeprazole 20mg/d. Subsequently, aspirin 100mg/…