A NOD2-dependent proteome signature pattern: implications for Crohn disease
P Rosenstiel, D Weichart, J Gobom, S Klopfleisch, R Häsler, N Gustavsson, H Lehrach, S Schreiber · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background & aims: NOD2, a cytosolic receptor for the bacterial proteoglycan fragment muramyl-dipeptide (MDP), plays an important role in the recognition of intracellular pathogens. Variants in the bacterial sensor domain of NOD2 are genetically associated with an increased risk for the development of Crohn disease, a human chronic inflammatory bowel disease. To understand the proteomic signature pattern associated with NOD2 dysfunction in Crohn disease, global protein expression changes after MDP-stimulation were analysed. Methods: Two-dimensional polyacrylamide gel electrophoresis of total protein extracts of…
