Pro12Ala mutation of peroxisome proliferator-activated receptor γ in patients with non-alcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver diseases ranging from simple fatty liver (steatosis), to nonalcoholic steatohepatitis (NASH), to cirrhosis as the irreversible, fibrotic form with advanced scarring of the liver. Peroxisome proliferator-activated receptor γ(PPAR γ) is a member of ligand-activated transcription factors and plays an important role in many cellular functions including lipid metabolism, cell proliferation, adipogenesis and inflammatory and fibrogenic signaling. In the present study, we tested the occurrence of the Ala12Pro mutation of the PPAR γ 2 gene assoc…