The Hypoxia inducible factor 1α (HIF-1α) regulates the malignant progression of gastric cancer

Introduction: Hypoxia is a hallmark of solid tumor growth and a negative predictor of patient survival. Adaptation to hypoxia is mainly achieved by the transcription factor HIF-1α, which is upregulated in a diverse range of human and experimental tumors and their metastases. HIF-1α target genes have been implicated in the induction of invasion and metastasis. Gastric cancer represents the second largest cause of cancer-related deaths worldwide. It has been shown that HIF-1α contributes to experimental gastric cancer pathogenesis. However, the underlying molecular and cell biological mechanisms have not been full…