New loci for restless legs syndrome map to chromosome 4q and 17p
J. Winkelmann, P. Lichtner, D. Kemlink, O. Polo, P. Montagna, B. Högl, K. Stiasny-Kolster, G. Hadjigeorgiou, B. Pütz, C. Trenkwalder, T.M. Strom, T. Meitinger, B. Müller-Myhsok · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: Three loci for RLS on chromosomes 12q, 14q and 9p (RLS1, RLS2 and RLS3) have been mapped, and evidence for further genetic locus heterogeneity has been shown. Methods: We conducted a genome-wide linkage analysis of a large RLS family of German origin. Results: Parametric two-point linkage analysis revealed a log odds (LOD) score of 2.3 and 2.1 and a multipoint LOD score of 3.08 and 2.78 on chromosome 4 and 17, respectively. Analysis was conducted under the assumption of an autosomal dominant model with full penetrance, an allele frequency of 0.003 and a phenocopy rate of 0.005. The disease associated…
