Neural substrates of word recovery in chronic poststroke aphasia: an fMRI study

We previously showed that the correlated activity between the left hippocampal formation and neocortical regions is important for the successful acquisition of a new lexicon in healthy subjects (cf. [1]). We here probed which neural structures show activity modulations from pre to post training in successfully trained aphasic patients. Five patients suffering from anomia after ischemic stroke were trained daily for two weeks in naming of concrete objects. Prior to and immediately after training, they overtly named 90 different objects during event-related fMRI. Thirty of the objects had been correctly named duri…