Modified „Bonn Protocol“ without intraventricular chemotherapy in the treatment of primary CNS lymphoma: preliminary results
H. Pels, A. Jürgens, A. Glasmacher, H. Schulz, M. Vogt-Schaden, M. Lamprecht, U. Bogdahn, H. Reichmann, I.G.H. Schmidt-Wolf, U. Schlegel · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Combined systemic and intraventricular chemotherapy (“Bonn protocol“) has achieved long term complete remissions and possibly cure in a substantial fraction of patients younger than 60 years with primary CNS lymphoma (PCNSL). However, infections of the Ommaya-reservoir in 20% of the cases overshadowed treatment results. Purpose: To evaluate whether intraventricular treatment is dispensable we omitted chemotherapy via an Ommaya reservoir in a phase II trial otherwise maintaining the systemic treatment. Patients and Methods: Fifty patients with histologically confirmed PCNSL were enrolled onto a phas…
