MTHFR 677TT genotype increases the risk for cervical artery dissections

Aims: Mean plasma concentrations of homocysteine are mildly elevated in subjects with homozygous MTHFR 677 TT genotype. As mild hyperhomocysteinemia is a risk factor for cardiovascular diseases the MTHFR 677TT genotype is considered as a risk factor for arterial diseases, too. It was found to be associated with increased carotid intima-media thickness (CIMT), ischemic invents and stroke. Mild homocysteinemia was typically found in patients with cervical artery dissections (CAD). However, the potential contribution of the MTHFR 677 TT genotype to the risk for cervical artery dissection (CAD) is unclear yet. Metho…