Cerebrospinal fluid proteome profile in patients with Guillain-Barre syndrome

Aims: Guillain-Barre syndrome (GBS) may be associated with severe progression and poor prognosis with a relatively high mortality. Due to its characteristic pattern, the cerebrospinal fluid (CSF) analysis helps confirming the diagnosis. However, there is still a need for a pathogenesis related biomarker for disease progression and outcome. Since the CSF is a source to investigate pathophysiological processes we intended to analyze the CSF proteome profile of GBS patients. Methods: Pooled CSF samples from patients with GBS (n=6; median age 53 years) were compared with neurologically normal controls (n=12; median…