Comparison of temporal activation patterns in fMRI and MEG studied in human auditory cortex

The time course of the BOLD response in auditory cortex shows complex dependence on sound sequence structure: A phasic onset response after about 6 seconds is more prominent for higher repetitions rates, while sustained activity decreases for high rates and long duty cycles. Stimulus adaptation of the neural response might explain part of this behavior, but sustained neural activity does not show a similar reduction with stimulus rate. Here we tested how neural and BOLD measures in auditory cortex compare when the same sound sequence is presented in MEG and fMRI. Sequences of click trains (F0=500Hz) were present…