CareLit Fachartikel

Genetic susceptibility towards breast cancer – First results from the HMBCS case-control association study

N Bogdanova, AN Nikolaevna, JH Karstens, P Hillemanns, T Dörk · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
808962
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
N Bogdanova, AN Nikolaevna, JH Karstens, P Hillemanns, T Dörk
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088620

Zusammenfassung

We present first results of the Hannover-Minsk Breast Cancer Study (HMBCS) that aims to elucidate the genetic basis of breast cancer susceptiblity in the ethnically homogeneous population of Belarus. We report twelve susceptibility alleles at eight genomic loci in a large case-control series of 1759 breast cancer cases and 1019 population controls. Three mutations in the BRCA1 gene (5382insC, 4153delA, T300G) and one mutation in the BRCA2 gene (6174delT) accounted for a total of 79 Byelorussian breast cancer patients (4.5%). In contrast with published data, the BRCA1*4153delA mutation was clearly associated with…

Schlagworte

ATM BRCA1 CHEK2 NBS1 low-penetrance susceptibility Geburtshilfe und Frauenheilkunde