CareLit Fachartikel
Adenosine receptor A2A expression is higher in placentas of women with preeclampsia
FM von Versen-Höynck, A Rajakumar, JM Roberts, C Bartz, W Rath, RW Powers · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
808967
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Hypoxia is a potent stimulus for the release of adenosine and angiogenic factors in tissues. Women with preeclampsia show evidence of placental hypoxia and increased concentrations of adenosine in the circulation. It is suggested that activation of adenosine receptors is an adaptive response to reduce hypoxic injury in different tissues. Objective: We tested the hypotheses that the adenosine receptor subtype A2A is expressed in the placenta, expression is altered in preeclamptic pregnancies and under in vitro hypoxic conditions. Methods: Placentas were obtained from primiparous women with uncomplicated pregnanci…
Schlagworte
adenosine
adenosine receptor
hypoxia
placenta
preeclampsia
Geburtshilfe und Frauenheilkunde
