CareLit Fachartikel
Validation of Plexin B1 as a prognostic and predicitive marker in gene expression datasets of 1363 breast cancer patients
A Rody, T Karn, E Ruckhaeberle, C Solbach, U Holtrich, M Kaufmann · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
808999
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Plexins, cell-surface receptors for semaphorins, are widely expressed in diverse epithelial cells and involved in cell adhesion and migration as well as in normal and malignant tissue. In previous work we could demonstrate for the first time that loss of plexinB1 expression is associated with poor outcome breast cancer patients. The goal of this work was an independent validation of plexinB1 expression in a large scale microarray data set of n=1137 breast cancer patients. PlexinB1 is strongly correlated with ER status (Mann Whitney p
Schlagworte
breast cancer
microarray analysis
plexinB1
prognosis
Geburtshilfe und Frauenheilkunde
