Efficacy of an oral contraceptive containing 0.030mg ethinylestradiol and 2mg dienogest (EE/DNG) for the treatment of acne – Comparison with placebo and with 0.035mg ethinylestrad…
TR Gräser, E Palombo-Kinne, I Schellschmidt · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Papulopustular acne is a common skin disease characterized, beside other factors, by androgenic stimulation of sebaceous glands. Combined oral contraceptives (COC) containing progestins with anti-androgenic properties (including e.g. dienogest [DNG]) are therefore suitable for the treatment of acne. The aim of this study was to show the non-inferiority of EE/DNG compared to EE/CPA (a well-established hormonal anti-acne treatment), and the superiority of EE/DNG compared to placebo. Methods: In a multicenter, double-blind, double-dummy, randomized clinical trial, healthy women between 16 and 45 years…