CareLit Fachartikel
Isolation, Characterization, and Potential Role of Cervical Stem Cells in HPV-induced Cervical Carcinogenesis
AC Baege, D Fink, C Baker, J Niederhuber · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
809016
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Convincing evidence exists that persistent infection with high risk HPVs is a necessary state for the emergence of cervical cancer. However, the crucial factors determining HPV persistence and development of precancerous and cancerous lesions are largely unknown. Our study was based on the hypothesis that viral persistence and subsequent initiation of cervical carcinogenesis may only arise from infection of cervical stem cells. We report on the successful isolation of a minor subpopulation of putative cervical stem cells with expression of distinct cell surface and common stem cell markers. These undifferentiate…
Schlagworte
HPV
HPV infection
carcinogenesis
cervical cancer
stem cells
Geburtshilfe und Frauenheilkunde
