Analysis of pregnane X receptor (PXR/NR1I2) gene variants in inflammatory bowel disease
J Seiderer, J Glas, J Diegelmann, C Tillack, S Pfennig, M Jürgens, T Griga, U Schiemann, W Klein, JT Epplen, T Mussack, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Aims: The pregnane X receptor gene (PXR/NR1I2) has recently been reported to be associated with susceptibility for inflammatory bowel disease (IBD). However, since a subsequent case-control study failed to replicate this association in an independent population, further replication studies in different ethnic cohorts are required. We therefore investigated this potential association in a large European IBD cohort. Methods: Genomic DNA from 2823 Caucasian individuals including 859 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1500 healthy unrelated controls was…
