Deletion of the platelet derived chemokine PF4 (CXCL4) limits liver fibrosis in vivo
M Moreno Zaldivar, K Pauels, M Berres, P Schmitz, N Gassler, C Weber, R Weiskirchen, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chemokines are inflammatory mediators during acute and chronic liver injury. The chemokine PF4 (CXCL4) is the only chemokine which is mainly secreted by platelets. PF4 has been shown to interact with RANTES (CCL5), thereby increasing monocyte arrest to endothelium. As RANTES has been shown to stimulate hepatic stellate cells and platelets are thought to contribute to liver fibrosis, PF4 might be an interesting novel mediator of liver injury. Methods: We induced liver fibrosis by CCl4 (6 weeks) and TAA (6 weeks) in PF4-/- mice and wild-type littermates. Fibrosis was analyzed by morphological staging of hist…
