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Fatty Acid Amide Hydrolase but not Monoacyl Glycerol Lipase Is a Crucial Determinant of Endocannabinoid-induced Cell Death in Hepatic Cell Populations

SV Siegmund, A Wojtalla, F Herweck, MV Singer · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
809403
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
SV Siegmund, A Wojtalla, F Herweck, MV Singer
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191800

Zusammenfassung

Background: We have shown that the endcannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) selectively induce cell death in activated hepatic stellate cells (HSCs), but not in hepatocytes. In contrast to HSCs, hepatocytes highly express the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) that protects them from AEA-induced injury. However, the hepatic expression pattern and function of the 2-AG-degrading enzyme monoacyl glycerol lipase (MGL) has not been investigated. Methods: MGL expression was analyzed by western blot and real time PCR in primary rat hepatocytes and primary rat HSCs. MGL or…

Schlagworte

Hepatic stellate cells endocannabinoids fatty acid amide hydrolase hepatocytes monoacyl glycerol lipase Zeitschrift für Gastroenterologie