The sirtuin activator represses glucokinase expression via the combined action of FoxO1 and HNF-4

Glucokinase (GK) plays a key role in promoting glucose utilization in the liver. Recently, it has been reported that the polyphenol resveratrol regulates several cellular processes among them fat and glucose metabolism. Although it was proposed that resveratrol may exert its effect via its target Sirt1 through deacetylation of FoxO1, the molecular mechanisms by which resveratrol affects glucose metabolism remain largely unknown. Therefore, it was the aim of the present study to better understand the role of resveratrol in the regulation of GK expression in the liver. Treatment of hepatocytes with resveratrol dos…