microRNA-198, downregulated in hepatocellular carcinoma, represses cell growth of hepatoma cells
N Elfimova, S Schievenbusch, A Noetel, M Kwiecinski, F Schulze, D Nierhoff, M Quasdorff, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression by targeting mRNAs through translational repression or RNA degradation. Many fundamental biological processes are modulated by miRNAs and an important role for miRNAs in carcinogenesis is emerging. We have shown by previous screening of dysregulated miRNA, that miRNA-198 (miR-198) is highly downregulated in HCV-positive hepatocellular carcinoma (1). In the present approach we studied the function of miR-198 in hepatocellular carcinogenesis. Methods: miR-198 level was analyzed in Huh7, Hep3B, HepG2, and Pop10 hepatoma cells and in hepa…
