p53 family-regulated apoptosis genes in hepatocellular carcinoma (HCC)
HM Mundt, AF Koch, AE Schulze Schleithoff, SJ Seitz, K Lorenz, W Stremmel, M Müller · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
The p53 family genes p53, p63 and p73 produce multiple isoforms that vary in composition of the NH2- and C-termini. The dominant-negative (ΔN) isoforms can oppose the transactivation capabilities of the full length (TA) proteins. The frequent inactivation of p53 and the expression of the ΔN isoforms of p63 and p73 in HCC indicate that abrogation of p53 family-dependent apoptosis could promote hepatocarcinogenesis and confer drug resistance. Therefore, in search for novel strategies to overcome resistance of HCC, this study was designed to characterize the downstream apoptosis genes and signaling pathways regulat…
