CareLit Fachartikel
Lower hepatitis B virus productivity in HBeAg negative patients is not due to accumulation of mutations within viral DNA regulatory regions
A Köpke, T Volz, M Lütgehetmann, AW Lohse, J Petersen, M Dandri · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
809417
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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zitierfähig
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Zusammenfassung
Understanding of factors regulating activity of the covalently closed circular DNA (cccDNA), the template of hepatitis B virus (HBV) transcription, is important to elucidate viral persistence mechanisms. Quantitative measurement of HBV DNA and cccDNA loads in human liver biopsies revealed that HBV replication pathway was significantly reduced in most treatment naïve HBeAg-negative individuals and impairment of virion production was not linked to the emergence of common HBeAg variants (Volz, Gastroenterology 2007). Here we studied whether genetic variability within the regulatory regions (Enhancer I and II) and t…
Schlagworte
Enhancer I
Enhancer II
HBV
X-ORF
cccDNA
regulatory region
virion productivity
Zeitschrift für Gastroenterologie
