Re-evaluation of the genetic cirrhosis risk score in patients with chronic hepatitis C virus infection
F Grünhage, T Müller, R Günther, C Hellerbrand, U Spengler, CP Strassburg, B Schlosser, V Weich, HE Wasmuth, F Lammert, T Berg · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Recently based on a genome-wide scan, a novel "gene signature" consisting of 7 single nucleotide polymorphisms (SNPs) has been proposed to identify patients at risk for cirrhosis in chronic hepatitis C virus (HCV) infection (Huang et al. Hepatology 2007;46: 297–306). However, this cirrhosis risk score (CRS) has yet to be replicated in an independent sample. Thus, our aim now was to evaluate the gene signature in a large independent cohort of patients with chronic HCV infection. Patients and methods: For this study, we recruited 490 German patients with chronic HCV infection. From liver biopsies, we determi…
