The SLC30A8 gene polymorphism R325W can stratify type 1 diabetes risk among ZnT8 autoantibody positive children
U Landherr, V Lampasona, K Koczwara, S Krause, T Illig, E Bonifacio, AG Ziegler, P Achenbach · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: This study was to test the hypothesis that autoantibodies to zinc transporter 8 (ZnT8) are an early component in the pathogenesis of childhood type 1 diabetes that can stratify diabetes risk upon existing islet autoantibody markers, and to evaluate the influence of allelic variation in the SLC30A8 gene encoding for different amino acids at position aa325 of the ZnT8 molecule on antibody-specificity and risk in non-diabetic children. Methods: ZnT8 autoantibodies were measured in sera from 1783 children with a first-degree family history of type 1 diabetes who have been prospectively followed from birth…
