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Functional characterization of SGK1 in medulloblastoma biology

S Pleier, D Sturm, M Remke, H Witt, V Goidts, G Reifenberger, J Felsberg, A Kulozik, A Korshunov, P Lichter, S Pfister · Klinische Pädiatrie · 2009 · Heft 05

Dokument
809803
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Pleier, D Sturm, M Remke, H Witt, V Goidts, G Reifenberger, J Felsberg, A Kulozik, A Korshunov, P Lichter, S Pfister
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222670

Zusammenfassung

Medulloblastoma comprises the most common malignant brain tumour in children and is associated with a comparably poor overall survival rate of only 60%. We performed microarray-based profiling on DNA-, RNA- and protein level to identify prognostic risk-groups. Based on this integrative genomics approach, we identified serum- and glucocorticoid-inducible kinase 1 (SGK1) as one of the most powerful prognostic markers. Interestingly, high expression of SGK1, a close homologue of the antiapoptotic kinase AKT1, is significantly associated with poor overall survival (p

Schlagworte

Klinische Pädiatrie