Exon-level gene expression analyses of primary neuroblastoma improves risk prediction and identifies JARID1C as a candidate target

Neuroblastoma (NB), the most common solid tumor of childhood, is characterized by a remarkable heterogeneity of patients' courses and survival rates of older patients with metastatic disease have remained poor. Numerous prognostic factors including amplification of the MYCN oncogene have been described. However, despite advanced clinical risk stratification, current trials still fail to determine the best treatment strategy for a substantial number of patients. On the route to clinical application of improved array-based classifiers to predict the risk profile of individual patients, significant progress has bee…