Immunmodulatory Effects of LPS of Clinically Relevant Pathogens to the Fetale Immune System in Pregnancy
E Schmalzbauer-Reuschel, L Deml, K Entleutner, U Zähringer, B Seelbach-Göbel · Zeitschrift für Geburtshilfe und Neonatologie · 2009 · Heft 04
Bibliografische Angaben
Zusammenfassung
The aim of our study was to investigate the role of gram negative bacteria frequently found in cervical swabs of pregnant women causing premature labor, rupture of membrance and premature delivery. Therefore, we stimulated cord blood PBMCs from mature pregnancies with purified LPS of E. coli, Klebsiella pneu., Proteus mir., Enterobacter aer., Acinetobacter cal., Citrobacter fr. and Pseudomonas aer. for 4h and 36h to determine the secretion of a broad panel of immunologically relevant cyto- and chemokines. In fetal blood we found IL–6, TNF, IL–1ß (pro-inflammatory-), IL–10, IL–13 (anti-inflammatory-), INF-y, IL12…
