Natural history of patients with acute on chronic liver failure: a single center experience

Acute on chronic liver failure (AoCLF), defined as acute deterioration of a patient with compensated liver disease, carries a high risk of mortality mainly due to multiorgan dysfunction. Several prognostic models have been discussed to predict the outcome of these patients. The aim of this study was to determine the natural history of patients with AoCLF referred to a tertiary center and to analyze predictive parameters for patient survival and the prognostic accuracy of the currently used models. Eighty-four consecutive patients with decompensated liver cirrhosis who required intensive monitoring and/or could n…