Imaging of somatostatin-receptor expressing neuroendocrine tumors (NETs) with Ga-68 DOTATOC-PET/CT versus In-111 DTPA-octreotide SPECT/CT

Aim: Imaging of somatostatin-receptor (STTR) expressing tumors using In-111 DTPA-octreotide (In-111 DTPAOC) has proven to be helpful in the detection of STTR expressing neuroendocrine tumours and their metastases. One of the disadvantages of this method is its limited sensitivity in detecting small lesions, even if SPECT-technique is applied. Ga-68 DOTA-D-Phe(1)-Tyr(3)-octreotide (Ga-68 DOTATOC) is a recently developed PET-radiotracer with – compared to In-111 DTPAOC – higher affinity to STTR2, a subtype most often expressed in NETs. This study compares the clinical performance of both methods in detecting STTR2…