T-cell intrinsic Smad7 determines Th1/Th17 differentiation and susceptibility to autoimmune encephalomyelitis
I Kleiter, J Song, D Lukas, M Hasan, A Croxford, C Becker, M Neurath, U Bogdahn, A Steinbrecher, A Waisman · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: T cells play an important role in the pathogenesis of multiple sclerosis and its model disease experimental autoimmune encephalomyelitis (EAE). The transforming growth factor (TGF)-β is a cytokine of great importance for T cell differentiation, proliferation and survival. While blocking T helper (Th)1 and Th2 differentiation, TGF-β is crucial for the generation of T regulatory (Treg) and Th17 cells. Objective: To investigate the role of Smad7, the intracellular inhibitor of TGF-β signalling, in T cell differentiation and in autoimmune inflammation of the CNS. Methods: We used conditional gene targeti…
