Long-term treatment with botulinumtoxin type A in non-dystonic facial spasms

Introduction: We present a retrospective analysis of 145 patients with non-dystonic facial spasms treated with botulinum toxin type A (BoNT; Botox® or Dysport®) in our movement disorder clinic between 1993 and 2008. Methods: Dysport® was diluted in 2.5ml 0.9% sodium chloride solution to produce a concentration of 200 units/ml and Botox® in 4ml 0.9% sodium chloride solution to give a concentration of 25 units/ml. BoNT dose per treatment and per treated muscle, global clinical improvement (GCI; 0 to 3; 0=no effect, 3=marked improvement), side effects, latency and duration of response were recalled from our databas…