Neuronal activation patterns of PD patients with deep brain stimulation depend on the location of active electrode poles in relation to the subthalamic nucleus

Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to activate energy metabolism in the target region and directly connected basal ganglia (BG) output nuclei in Parkinson's disease (PD).1 Active electrode poles for maximal clinical benefit in STN-DBS were located to the upper and lateral border of the STN in the near of fiber tracks passing through the zona incerta. In this study, we intended to investigate effects of acute DBS on BG activity in patients with intra- and extranuclear electrode location using 18-FDG positron emission tomography (PET). Methods: The resting cereb…