Primary papillary carcinoma of the peritoneum: analysis of putative target molecules (COX-2, HER-2/neu Steroid -hormone receptors)

Purpose: Primary peritoneal carcinomas (PPC) are rare but aggressive malignancies. Evaluating therapeutic relevant molecules PPC were investigated immunohistochemically. Methods: 26 PPC were stained with antibodies against estrogen and progesterone receptors, HER-2/neu and COX-2 with semiquantitative evaluation of the staining results. Results: Twentyone out of the 26 PPC (80;8%) were negative or showed only weak expression for estrogen receptor. One half of the tumors showed moderate or strong positivity for progesterone receptor. Only three PPC (11;5%) showed strong immunoreaction for HER-2/neu (Score 3). Near…