Severe exacerbation of chronic hepatitis B viral infection due to Cushing's disease

Introduction: Exacerbation of chronic hepatitis B viral infection may be observed spontaneously or more common after iatrogenic immunosuppression either due to chemotherapy or due to chronic administration of immunosuppressive drugs such as corticosteroids. In the pre-HAART era, exacerbation of HBV infection was also observed in patients with deteriorating CD4 cells. However, acquired endogenous immunosuppression due to elevated cortisol excretion is rarely observed. Case: We present a patient with severe exacerbation of HBV infection due to Cushing's disease. A 55 years-old woman presented to our outpatient dep…