HER2neu-Expression beim Magenkarzinom: selten, heterogen und ohne prognostische Bedeutung – Eine immunhistologische Untersuchung an 924 Fällen zweier unabhängiger Tumorserien

Aims: Patients with gastric cancer (GC) have a poor survival and biologicals such as Trastuzumab have not been used routinely in these patients. Studies in breast cancer indicate that response to Trastuzumab depends on membranous HER2 overexpression or HER2 amplification. Existing data on the clinical relevance of HER2 expression in GC are still limited and controversial. Methods: HER2 expression was investigated by immunohistochemistry using full sections from 418 GC from Germany (series A) and tissue microarrays constructed from 506 GC from England (series B). The 'DAKO score' and a continuous percentage scale…