CareLit Fachartikel
Synthesis of intracellular aliphatic polycations, involved in hepatocancerogenesis is regulated by hepatotrophic factor ALR
R Dayoub, W Thasler, A Bosserhoff, KW Jauch, HJ Schlitt, TS Weiss · Zeitschrift für Gastroenterologie · 2007 · Heft 01
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812182
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Jahr
2007
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Zusammenfassung
Small molecules like aliphatic polycations, named polyamines, were proven to be essential for hepatic growth and regeneration. Additionally, different stages of liver regeneration are regulated by a variety of factors such as the liver growth associated protein ALR, augmenter of liver regeneration. Also, increased ALR levels were detected for various types of acute liver disease, and in addition, we could find increased expression of ALR in livers from patients with cirrhosis, hepatocellular and cholangiocellular carcinoma [1]. On the other hand polyamines are known to contribute to carcinogenesis and tumour pro…
Schlagworte
growth factors
liver regeneration
polyamines
proliferation
signal transduction
Zeitschrift für Gastroenterologie
