FoxO1 ablation in hypothalamic pomc neurons reduces food intake and body weight

Insulin and leptin control food intake in part by regulating the transcription of orectic and anorectic neuropeptides in the hypothalamus. Activation of insulin receptor signaling results in nuclear exclusion of the transcription factor forkhead box-containing protein of the O subfamily (FoxO)-1, while Leptin activates the signal transducer and activator of transcription 3 (Stat3). We have previously shown that FoxO1 and Stat3 exert opposing actions on the expression of Agrp and Pomc, resulting in activation of Agrp and inhibition of Pomc transcription. We reported that hypothalamic adenoviral delivery of consti…