Mucosal expression of Toll-like receptor (TLR) 2 and TLR4 in treated coeliac disease
B Szebeni, G Veres, A Dezsőfi, Á Vannay, B Vásárhelyi, I Korponay-Szabó, A Arató · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: The dysregulation of adaptive immunity has been extensively investigated in coeliac disease (CD). Recent data also suggest, however, the implication of innate immunity in CD. Toll-like receptors (TLRs) play a central role in the initiation or maintenance of innate immune responses. Previously we have found higher TLR2 and TLR4 mRNA expression and protein levels in the duodenal mucosa of children with untreated CD than in controls. Aim: The aim of this study was to characterise the expression of TLR2, TLR3 and TLR4 in duodenal biopsy samples taken from children with treated CD compared to untreated CD and c…
