The effect of thiazolidinediones on leucocytes in type II diabetic patients

Objective: To investigate the effect of thiazolidinediones, which are peroxisome proliferator-activated receptor gamma (PPARgamma) ligands used to treat diabetes mellitus. In particular our study is interested in the effect of rosiglitazone in the number of leucocytes knowing that it causes reduction of haemoglobin and haematocrit mainly due to water retention. Materials – methods: In 25 patients,12 men and 13 women, already under insufficient hypoglycaemic control (mainly under glibenclamide) 4mg/die of rosiglitazone were added.5 of them had positive hypertensive anamnesis and in 8 hypertension was newly diagno…