Polyneuropathy: an important hint for early diagnosis of amyloidosis?

Amyloidosis is a rare multisystemic disease caused by a deposition of immunoglobulin light chain fragments in a variety of tissues. Clinical signs of amyloidosis are vague and include neuropathy, fatigue, myopathy and cardiac or renal failure. The most common neuropathy associated with systemic amyloidosis is a small-fiber axonal polyneuropathy that is characterized by amyloid deposits in the epi-, peri-, and endoneurium of the peripheral nerves. Here, we report of a 75-year-old woman who was initially admitted to the department of internal medicine with symptoms of fatigue, hypotension, diarrhoea and a reduced…