Alertness dysfunction in MS: structural lesions and functional consequences

Introduction: Recent studies have shown that both grey and white matter lesions contribute to mental dysfunction in MS. The relation between lesion localization and its functional consequences however has not yet been clarified. Methods: Twenty-two MS patients recruited in two different sites participated in this study. All patients were investigated with a computerized alertness task. MRI data acquisition included T1 and T2 weighted images in all patients. MRI lesion analysis was performed using different methods. In the first site, 12 patients were classified according to an in-house routine (Bochum-Langendree…