Characterization of mononuclear cell response in the blood after acute ischaemic stroke – possible mechanisms for central nervous injury immune deficiency syndrome (CIDS)

Background and purpose: Acute stroke causes severe immuodepression which leads to high infection rates and has negative effects on stroke outcome. As mononuclear cells (MC) play a major role in the immunosystem, their response to acute ischaemic stroke was characterized over a period of three days after symptom onset. Methods: Patients with the diagnosis of acute ischaemic stroke and symptom onset below 6 hours were prospectively included into the study. Besides routine parameters, subpopulations of CD3+ [T-lymphocytes], CD14+ [monocytes]-, CD19+ [B-lymphocytes]-, and CD68+ [macrophages]-positive cells expressin…