Hormonal regulation of the 'Ileal Brake' in human

Ileal nutrients inhibit upper gastrointestinal transit and gastropancreatic secretion. This 'ileal brake' is a feedback mechanism controlling meal transit and digestion. The gut hormones GLP-1 and PYY mainly originating from the lower small intestinal L-cells are postprandially released. Still, the importance of the predominant presence of L-cells within the lower gut is obscure. Since the synthetic peptides inhibit gastropancreatic secretions, they are candidate humoral mediators of the ileal brake. Accordingly, we examined the effects of ileal nutrients on pancreatic enzyme and gastric acid secretions employin…