HRT and breast cancer risk

Introduction: A number of controversial studies have been reported on the potential risk of breast cancer caused by hormone replacement therapy (HRT). Methods: . To clarify the contradictory outcomes in the relationships between HRT and the onset of breast cancer, we reviewed the literature. Results: Recent analyses of the WHI data and other randomised controlled trials suggest that, although there are potential side effects and risks involved in taking HRT, these may be reduced by: using lower HRT doses; minimising or eliminating systemic progestogens; using non-oral routes in some women; and initiating HRT in…