Neoadjuvant hormonal treatment of locally advanced breast cancer

The potential goals of neoadjuvant treatment for locally advanced breast cancer (LABC) include downsizing tumors to allow breast conservation as well as the possibility of improving survival rates. Most of the published evidence relates to the use of neoadjuvant chemotherapy rather than hormonal therapy. However, it has been well established that adjuvant hormonal therapy is the most effective adjuvant treatment of hormone-sensitive tumors, particularly in post-menopausal women. It is therefore logical to hypothesize that neoadjuvant hormonal therapy is as least as effective as chemotherapy in these patients. Ea…