Different profibrogenic impact of Il–13 and TGF-β strongly depends on the etiology of damage
HL Weng, JL Chen, Y Liu, P Godoy, T Huang, C Zhou, HK Seitz, F Stickel, A Marx, PR Mertens, S Dooley · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
TGF-β is pro-fibrogenic in liver fibrosis. A few studies demonstrated that TGF-β was not critical in fibrogenesis in Schistosomiasis infected mice or patients. Instead, IL–13 was identified. We measured Smad2 phosphorylation in 242 liver tissues from patients with chronic HBV, HCV and Schistosoma japonicum infection and related the data to (steato)hepatitis. Strong phospho-Smad2 staining was found in HBV patients, while it was weak or negative in HCV infected tissues. Phospho-Smad2 was detected in hepatocytes, bile duct epithelial cells, hepatic stellate cells (HSCs), Kupffer cells and inflammatory cells. With t…
