CareLit Fachartikel
The selective induction of apoptosis in HSC by the targeted thymidine kinase/Ganciclovir system
E Kovalenko, E Borkham-Kamphorst, M Bomble, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
814529
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Jahr
2008
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Zusammenfassung
Background/Aims: Liver fibrogenesis is the consequence of a dysbalance of synthesis and degradation of extracellular matrix components. During hepatic fibrogenesis, hepatic stellate cells (HSC) are the major producer of these constituents. Therefore, HSC are in the focus of antifibrotic therapies. A previous report from us have demonstrated that the thymidine kinase/Ganciclovir system directed under transcriptional control of the tissue inhibitor of metalloproteinases–1 (TIMP–1) promoter is suitable to induce apoptosis in culture-activated HSC [1]. We now extended our studies and tested if a selective induction…
Schlagworte
adenoviruses
antifibrotic therapy
gene therapy
tissue inhibitor of metalloproteinases-1
transcriptional targeting
Zeitschrift für Gastroenterologie
