CareLit Fachartikel
Profibrogenic effects of BMP–9 via activation of the ALK–1/Smad1 pathway in hepatocytes
K Breitkopf, E Wiercinska, A Müller, P ten Dijke, S Dooley · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
814530
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
It is well known that TGF-β1 represents a central mediator of liver fibrogenesis by inducing pro-fibrogenic target gene expression in hepatic stellate cells (HSCs) and recent results from our group show similar responses to TGF-β also in hepatocytes (HCs). However, there seem to be other TGF-β super-family members involved in this process as well. In this study, we investigated the expression and signalling of bone morphogenetic protein (BMP)–9 (also called GDF2) in primary HCs and HSCs in vitro and performed experiments of BMP–9 neutralization plus CCl4 induced fibrogenesis in mice in vivo. While HSCs responded…
Schlagworte
BMP-9
TGFbeta
fibrosis
hepatic stellate cells
hepatocytes
Zeitschrift für Gastroenterologie
