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Transcriptional activity of Serum Response Factor is mediated by the RhoA/Rho kinase pathway during HSC differentiation and influences expression of Smooth Muscle Cell marker genes

J Herrmann, U Haas, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2008 · Heft 01

Dokument
814531
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Herrmann, U Haas, AM Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1037500

Zusammenfassung

Hepatic stellate cells (HSC) are prominent cellular effectors of liver fibrosis, which become activated during liver injury and transdifferentiate from quiescent, fat storing cells into a proliferative myofibroblastic cell type (MFB). This process is accompanied by modulations of gene expression. A common feature of activated HSC is upregulation of genes encoding known markers of smooth muscle cells (SMC), e.g. α-smooth muscle actin (α-SMA). In SMC, these genes are regulated by the ubiquitous transcription factor serum response factor (SRF) in cooperation with specific co-factors, especially myocardin. As SRF be…

Schlagworte

Gene Regulation HSC Liver Fibrosis SRF Smooth Muscle Cell Marker Zeitschrift für Gastroenterologie